Journal: Pharmacological Reviews

Article Title: Current Challenges and Opportunities in Treating Glioblastoma

doi: 10.1124/pr.117.014944

Figure Lengend Snippet: CNS MPO Version 2 scores were calculated for 73 of the GBM drug candidates listed in . Plots are shown for scores calculated for total CNS MPO score (A), molecular weight distribution (B), LogP value distribution (C), polar surface area value distribution (D), hydrogen bond donor total distribution (E), and p K a value (of the most basic center) distribution (F).

Article Snippet: To ameliorate this problem, a CNS multiparameter optimization (CNS MPO) algorithm was designed by Pfizer scientists with the goal of streamlining the CNS drug discovery process ( ).

Techniques: Molecular Weight

Journal: Molecules

Article Title: Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

doi: 10.3390/molecules27103173

Figure Lengend Snippet: HPLC-logD and CNS MPO score of the synthesized hydroxylated arecaidine esters.

Article Snippet: To address this multifariousness, which is equally important in the context of classical drug design, a group of medicinal chemists around Travis Wager from Pfizer developed the CNS MPO (multiparameter optimization) score [ ].

Techniques: Synthesized

Journal: Communications Biology

Article Title: Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy

doi: 10.1038/s42003-020-0826-3

Figure Lengend Snippet: The values are colour coded according to Wager , . Green; the values fall in more desirable range, red: the values fall in less desirable range, yellow: the values fall in-between the ranges. ClogP: calculated logarithm of partition coefficient of a compound between n-octanol and water, ClogD: calculated logarithm of distribution coefficient of a compound between n-octanol and water at pH 7.4, MW: molecular weight, tPSA: topological polar surface area, CNS MPO: central nervous system multiparameter optimisation.

Article Snippet: Figure contains key data for the series (ClogP, ClogD, MW, TPSA) along with data generated by the Pfizer central nervous system multiparameter optimisation (CNS MPO) algorithm with CNS MPO desirability scores .

Techniques: Molecular Weight